KLK3 and pachyonychia congenita: These findings are relevant in patients who achieve an undetectable PSA with further follow-up and have no or at most 1 high-risk factor at RP (T3 or T4 disease or Gleason score of 8 to 10) given the randomized data suggesting no benefit in metastasis-free survival for adjuvant compared with early salvage RT.16 For patients with 2 or more high-risk factors17 or pN1 PC,18 adjuvant RT may be indicated, given it is associated with reduced ACM risk.