COL8A2 and Fuchs endothelial corneal dystrophy: Despite 10% (13/128) of the exome-sequenced Exp- cases harboring rare qualifying variants in previously reported FECD genes, only one COL8A2 variant (p.Gln455Lys) has previously been robustly demonstrated as an established cause of FECD.26,28,67 Additional analysis is required to validate all remaining variants reported here.