The eight features were significantly different (p < 0.05) between Gene+ and Gene− groups were selected for the determination of the pediatric Mo‐CVID score: family history of IEIs, severe infections, infections with sequelae, pan hypogammaglobulinemia (IgG, IgA, IgM deficiency), absence of switched memory B cells (<0.30%, 5 cells) of total B lymphocytes, ≥3 autoimmune manifestations, ≥2 lymphoproliferative manifestations, and clinical onset <4 years or CVID diagnosis <7 years (Figure 2). This evidence concerns the gene CD79A and Decreased circulating total IgM.