Considering the patients with mutations in typical CVID‐genes we identified two patients with biallelic mutations (one compound heterozygous and one homozygous) in the transmembrane activator and calcium‐modulating cyclophilin ligand interactor (TACI, TNFRSF13B) that were considered causative of the CVID phenotype. The gene discussed is TNFRSF13B; the disease is common variable immunodeficiency.