By forcing the preceding four factors into the multivariate linear regression model, NIHSS scores (beta, 0.133; 95% CI, 0.088–0.178; variance inflation factor (VIF), 2.326; p = 0.011), and hematoma volume (beta, 0.051; 95% CI, 0.037–0.064; VIF, 2.857; p = 0.001) were independently correlated with serum MLKL levels. This evidence concerns the gene MLKL and hematoma.