STK11/LKB1 loss of function alterations enhance cell proliferation and promote cancer cell growth, motility, and invasion, thus enhancing metastatic potential.34,35 However, the other two genetic alterations enriched in lung-only mPDAC do not unquestionably bestow an aggressive tumor characteristic; a finding that differs from that of liver-only mPDAC. Here, STK11 is linked to cancer.