ITGB4 and osteosarcoma: Additionally, hubs such as SRC, STAT1, IL6, FN1, CD44, IL1B, MMP‐2, ITGB3, ITGB4, and COL1A1 have demonstrated participation in pathways associated with metastasis, invasion, migration, and EMT in osteosarcoma and various cancers, implying their involvement in the regulation of these pathological processes [51, 52, 53].