For example, malignant cells from patients with B-cell non-Hodgkin lymphoma (B-NHL), including diffuse large B cell lymphoma, (DLBCL), mantle cell lymphoma, (MCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL), exhibited elevated CD47 expression (average 2-fold) compared to normal B cells in the periphery and in germinal centers (2). The gene discussed is CD47; the disease is diffuse large B-cell lymphoma.