Microarray technology reveals differential lncRNA expression between exhausted and non-exhausted CD8+ T-cell exosomes, highlighting the upregulation of tumor-promoting genes like SUMF2 and CHCHD1, and the downregulation of tumor-suppressing genes like UBXN10 in lncRNA of exhausted CD8+ T cell-derived EVs, indicating their potential in promoting tumor growth (65–69). Here, CD8A is linked to neoplasm.