S100A4 expression in mouse liver macrophages was shown to be driven by the CX3CR1/Myd88/NF-κβ signaling axis, and targeting this pathway alleviated liver fibrosis in a high-fat diet-driven mouse model of metabolic dysfunction-associated fatty liver disease (MAFLD) in vivo (55) (Figure 1b). Here, S100A4 is linked to Hepatic fibrosis.