In mouse models of breast cancer, S100A4 promotes the recruitment of pro-tumor Th2 polarized CD4 T cells to both the primary tumor and metastatic sites to promote disease progression (91, 108, 121), and antibody blockade of S100A4 reduces CD3+ T cell infiltration in the primary tumor and lung metastasis (90). The gene discussed is S100A4; the disease is breast carcinoma.