Using an S100a4-GFP knock-in reporter mouse with syngeneic mouse glioma models, we previously showed that GFP+ glioma infiltrating CD4 T cells from S100a4 -/- mice had reduced ability to inhibit T cell proliferation in vitro compared with their counterparts from S100a4 GFP/+ mice (15). This evidence concerns the gene CD4 and glioma.