The interferon (IFN)-like response mediated by TAK-981 inhibits the differentiation of Treg cells while enhancing various cytotoxic features of primary chronic lymphocytic leukemia (CLL)-derived CD8+ T cells, including degranulation (CD107a), and upregulated perforin, Granzyme B, and IFN-γ expression activity (46). Here, CD8A is linked to B-cell chronic lymphocytic leukemia.