For instance, deficiency of thioredoxin 2 (Trx2) in adipose tissue results in the stimulation of NFκB, which mediates the accumulation of the autophagy receptor p62, leading to mitochondrial autophagy and subsequently promotes insulin resistance and lipid metabolism disorders in T2DM, thereby linking NF-κB to metabolic disorders associated with insulin resistance (112). This evidence concerns the gene NFKB1 and Insulin resistance.