For instance, deficiency of thioredoxin 2 (Trx2) in adipose tissue results in the stimulation of NFκB, which mediates the accumulation of the autophagy receptor p62, leading to mitochondrial autophagy and subsequently promotes insulin resistance and lipid metabolism disorders in T2DM, thereby linking NF-κB to metabolic disorders associated with insulin resistance (112). The gene discussed is NFKB1; the disease is metabolic disease.