Receptor tyrosine kinase-like orphan receptor 1 (ROR1), typically absent or minimally expressed in normal tissues, and over-expressed in R/R DLBCL, interacts with Wnt-related proteins, promoting tumor cell proliferation, activation, and epithelial-to-mesenchymal transformation through the Wnt/β classical pathway and PI3Kδ/AKT/mTOR non-classical Wnt pathway (11). The gene discussed is ROR1; the disease is neoplasm.