The two-factor prognostic model is based on Eastern Cooperative Oncology Group (ECOG) PS and albumin levels (ECOG PS >1 and albumin ≤4.1), with each parameter assigned a point, categorizing newly diagnosed PCNSL patients into three risk groups (Low-risk group: 0 points; Intermediate-risk group: 1 point; High-risk group: 2 points). This evidence concerns the gene ALB and primary central nervous system lymphoma.