The pathological subtypes of R/R B-NHL in this cohort were DLBCL, primary mediastinal lymphoma (PML), primary central nervous system lymphoma (PCNSL) and high-grade B-cell lymphoma (HGBL) with MYC and/or BCL2/BCL6 rearrangement. This evidence concerns the gene BCL2 and mediastinal malignant lymphoma.