In addition, individuals with DS develop amyloid-beta peptide (Aβ) senile plaques, tau-containing neurofibrillary tangles, cortical thinning, and overt brain atrophy over their lifespan (Chapman and Hesketh, 2000; Mann et al., 1984; Lott and Head, 2019; Wisniewski et al., 1985). Here, APP is linked to Dravet syndrome.