TRPC3 and breast cancer: In a study on the mechanism of action of polyunsaturated fatty acids (PUFAs) on breast cancer, it was found that TRPC3 channels were highly expressed in MCF-7 breast cancer cells, and TRPC3 antagonists attenuated the proliferation of breast cancer cells, and that PUFAs directly inhibited TRPC3 in MCF-7 cells, which could be a potential target for the development of new anticancer drugs (Riehle et al., 2018).