During lung adenocarcinoma (LUAD) development, CBX4, a chromobox protein facilitates PHGDH transcription through interaction with GCN5, inducing increased histone acetylation on the PHGDH promoter, subsequently increasing serine biosynthesis and promoting LUAD proliferation (Zhao et al., 2024). Here, PHGDH is linked to lung adenocarcinoma.