Another study found that Alzheimer’s disease patients’ levels of natural Tregs are correlated with the levels of NFT and Tau.53 Levels of tau have also been shown to predict the rate of CD.135,136 As increasing Tregs can restore cognitive function,59,60 this together implies that increasing Tregs could also reduce levels of tau. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.