Some studies have shown that a depletion of Tregs results in increased Aβ plagues.59,131 Supporting this, other studies have demonstrated that increased levels of Tregs lead to increased Aβ plague clearance.39,61‐63,132‐163 Contrasting this, Dansokho et al. 60 found that there was no significant difference in Aβ burden in Treg-depleted APP/PS1 and non-depleted mice, although it was found that decreases in plaque-associated microglial activity and it was concluded that Tregs have a neuroprotective effect on Alzheimer’s disease models. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.