Adding to this, it has been shown that Tregs suppress microglia, which have been shown to accelerate development of NFT.63 It would be interesting to see more studies focusing on the impact of increased Tregs on tau pathogenesis in Alzheimer’s disease as there is limited research available on this concept, although it is clear from current research that there are various mechanisms triggered by an increase in Tregs that lead to reduced tau pathogenesis. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.