Another way that Tregs can act to modulate neuroinflammation is by producing immunosuppressive cytokines, such as interleukin 10 (IL-10), interleukin 35 (IL-35) and transforming growth factor beta.104 Cytokines play an important role in regulating immune responses and therefore can modulate neuroinflammation in Alzheimer’s disease. This evidence concerns the gene IL10 and Alzheimer disease.