FOXP3 and early-onset autosomal dominant Alzheimer disease: There is sufficient evidence to suggest that interleukin-2 (IL-2) improves amyloid pathology and memory in Alzheimer’s disease mice.108 Interestingly, IL-2 also boosts the suppressive function of Tregs not only suggesting that Tregs also may a role in improving Alzheimer’s disease hallmarks but also highlighting IL-2 as a potential target for Treg enhancement and Alzheimer’s disease treatment.108,109 IL-2 is necessary for Foxp3 expression and signalling to maintain survival of Tregs,110,111 thus vital for development and stability.