Terminally differentiated effector T cells (TEMRA) are associated with CD and Alzheimer’s disease, having a more cytotoxic phenotype, also connected with neurodegeneration, neuroinflammation and plasma markers of AD.130 More specifically, CD8+ TEMRA cells were shown to be associated with neural injury and Alzheimer’s disease, whereas CD4+ TEMRA have a role in the interplay of inflammatory mechanisms and CD8+ activation.130. Here, CD4 is linked to early-onset autosomal dominant Alzheimer disease.