For example, IL-10 suppresses inflammation by inhibiting the secretion of IL-1β, IL-6 and tumour necrosis factor alpha by microglia.105 A study by Le Page et al. 58 found IL-10 levels to be higher in both Alzheimer’s disease and MCI patients in comparison to healthy controls. This evidence concerns the gene IL6 and early-onset autosomal dominant Alzheimer disease.