The analysis of the Binary logistic regression after adjusting for age, sex, education, BMI, hypertension, and diabetes mellitus revealed an increased odds ratio (OR) associated with interquartile range (IQR) increases in Parkin levels among PD participants (Q4/Q1 = 8.07, p for trend = 0.017, Figure 4A and Supplementary Table 5). This evidence concerns the gene PRKN and diabetes mellitus.