We found that Parkin was significantly positively correlated to asy-no (r = 0.453, p < 0.001, Supplementary Figure 1A) and p-asyn (r = 0.428, p < 0.001, Supplementary Figure 1B), indicating the probable interaction of Parkin and a-syn in the PD pathogenesis. Here, PRKN is linked to Parkinson disease.