TTR and cardiac amyloidosis: Cardiac amyloidosis has garnered increasing attention over the past decades, as cardiac involvement is now recognized as a leading cause of mortality in this multi-system disease.1,2 Extracellular deposition of insoluble β-sheet fibrillar proteins in the heart has been identified in 30 different types of amyloidosis.3 Among these, immunoglobulin-derived light chains and transthyretin are the most common culprits, causing amyloid light-chain and transthyretin cardiac amyloidosis, respectively.