Multivariate Cox regression analysis revealed that children with Primary Nephrotic Syndrome (PNS) exhibiting a Neutrophil-to-Lymphocyte Ratio (NLR) of ≥ 2.90 and C-reactive Protein (CRP) levels of ≥ 20.30 ng/ml faced an elevated risk of recurrence within one year, as well as complications such as bone metabolism abnormalities, renal insufficiency, and secondary hypertension. Here, CRP is linked to Renal insufficiency.