Multivariate Cox regression analysis revealed that children with Primary Nephrotic Syndrome (PNS) exhibiting a Neutrophil-to-Lymphocyte Ratio (NLR) of ≥ 2.90 and C-reactive Protein (CRP) levels of ≥ 20.30 ng/ml faced an elevated risk of recurrence within one year, as well as complications such as bone metabolism abnormalities, renal insufficiency, and secondary hypertension. This evidence concerns the gene CRP and paraneoplastic neurologic syndrome.