This study employed multifactor Cox regression analysis to identify prognostic risk factors and found that a neutrophil-to-lymphocyte ratio (NLR) of ≥ 2.90 and a C-reactive protein (CRP) level of ≥ 20.30 ng/ml are significant risk factors for poor prognosis in children with primary nephrotic syndrome (PNS) within one year. Here, CRP is linked to paraneoplastic neurologic syndrome.