The results showed that the serum A20 level, duration of T2DM, hypertension, use of insulin and GLP-1 receptor agonists were positively correlated with lumbar spine 1-4 BMD and FPG was negatively correlated with lumbar spine 1-4 BMD (P<0.1). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.