CD4 and chronic kidney disease: In the CKD dataset, the CKD case group was significantly up-regulated in B memory cells, γ-δ T cells, plasma cells, activated mast cells, M1 macrophages, activated dendritic cells, and CD8+ T cells (p < 0.05), and significantly down-regulated in resting CD4+ T cells, M0 macrophages, activated CD4 + memory cells, and resting B cells (p < 0.05).