The HL animals showed severe dyslipidemia, atherogenesis and left ventricular hypertrophy, associated with a decrease in serum HDL-cholesterol levels and subsequent development of cardiovascular inflammatory process.Swimming and propolis alone and\or associated prevented the LVH, atherogenesis and arterial and ventricular inflammation, decreasing the CD40L expression and increasing the HDL-cholesterol plasmatic levels. The gene discussed is CD40LG; the disease is left ventricular hypertrophy.