It has been demonstrated that TMZ-resistant GBM cells show increased long-chain fatty acids levels and reduced PUFAs as a result of upregulation of fatty acid synthase (FASN), and a downregulation of delta-6-desaturase (D6D), the key enzyme for PUFA biosynthesis (Figure 5C) (Kao et al., 2023). Here, FADS2 is linked to glioblastoma.