In an orthotopic GBM mouse model, mTOR2 complex (mTORC2) activation has been shown to induce H3 histone acetylation, promoting the transcription of iron-related genes, including TfR1, FTL and ferritin heavy chain (FTH1), which in turn enhances the survival of GBM cells (Figure 4) (Masui et al., 2019). Here, TFRC is linked to glioblastoma.