Ferritin upregulation is associated with the epithelial-mesenchymal transition (EMT) and chemoresistance in glioma under hypoxic conditions, by activating the AKT/Glycogen synthase kinase-3 beta (GSK3β)/β-catenin signalling pathway (Figure 4) (Liu et al., 2020). The gene discussed is GSK3B; the disease is central nervous system cancer.