FTH1 and glioblastoma: In an orthotopic GBM mouse model, mTOR2 complex (mTORC2) activation has been shown to induce H3 histone acetylation, promoting the transcription of iron-related genes, including TfR1, FTL and ferritin heavy chain (FTH1), which in turn enhances the survival of GBM cells (Figure 4) (Masui et al., 2019).