In the hippocampi of AD mouse models, increased levels of fission proteins like Drp1 and Fis1 and decreased levels of fusion proteins like Mfn1, Mfn2, and Opa1 were observed, suggesting disrupted mitochondrial dynamics in these models (Kandimalla et al., 2018; Manczak et al., 2018). Here, DNM1L is linked to Alzheimer disease.