Significantly, dysregulation of Drp1-mediated mitochondrial fission is closely associated with a spectrum of chronic non-communicable diseases (Kleele et al., 2021), including neurodegenerative diseases (Wu et al., 2017; Medala et al., 2021; Oliver and Reddy, 2019), cardiovascular diseases (Umezu et al., 2020; Huan et al., 2023), and metabolic disorders (Wada and Nakatsuka, 2016). Here, DNM1L is linked to neurodegenerative disease.