Accordingly, identified risk genes for neurodevelopmental disorders encode for various constituents of GABAergic synaptic transmission, including GABA receptors, inhibitory synaptic proteins and chloride transporters, but also cause dysfunctions in the generation, migration and survival of inhibitory neurons (Tang et al., 2021), suggesting that malfunctions at the level of GABAergic interneurons and/or GABAergic synapses can contribute to the etiology of such diseases (Ben-Ari et al., 2012; Coghlan et al., 2012; Dienel and Lewis, 2019). This evidence concerns the gene PROS1 and neurodevelopmental disorder.