The signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in cell proliferation, angiogenesis, and immunosuppression, and its overactivation often leads to the development of cancer and poor clinical prognosis (Johnson et al., 2018; Hanlon et al., 2019; Ouyang et al., 2022). This evidence concerns the gene STAT3 and cancer.