BRD4 and cancer: It has been shown that BRD4 proteins are involved in the development of a variety of cancers, and their alterations are considered to be an important oncogenic driver that causes or maintains malignant growth, so BRD4 has become an attractive cancer therapeutic target (Fong et al., 2015; Bechter and Schoffski, 2020; He et al., 2020; Andrikopoulou et al., 2021).