NFE2L2 and breast carcinoma: For example, overexpression of miR-27a increases mitochondrial ROS levels by attenuating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway and the glutathione synthesis in MCF-7 cells, rendering them more sensitive to paclitaxel or doxorubicin (DOX), two conventional chemotherapy drugs for breast cancer (Ueda et al., 2020).