MTOR and hepatocellular carcinoma: Moreover, increased mitochondrial autophagy was found to confer greater cisplatin resistance, and the use of phosphatidylinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors can disrupt this crosstalk and increase the sensitivity of HCC cells to cisplatin (Sheng et al., 2019).