Similarly, Xu et al. found that in sorafenib-resistant hepatocellular carcinoma (HCC) cells, peroxisome proliferator-activated receptor γ coactivator 1β (PGC1β) degrades, leading to ROS decline and thereby protecting mitochondrial function and integrity, all of which contribute to development of resistance (Xu et al., 2021). This evidence concerns the gene PPARGC1B and hepatocellular carcinoma.