While UCHL1 is known to be predominantly expressed in the brain and plays a central role in neurodegenerative diseases (Zhang et al., 2014; Das et al., 2006; Day and Thompson, 2010; Setsuie and Wada, 2007), studies have also established its function in ovarian development and fertility (Woodman et al., 2022). This evidence concerns the gene UCHL1 and neurodegenerative disease.