AKT1 and Cognitive impairment: Moreover, rehmannioside A, which is derived from RG, has neuroprotection effects and improves cognitive impairment by inhibiting ferroptosis and activating the PI3K/AKT/Nuclear factor erythroid 2–related factor 2 (Nrf2) and solute carrier family 7 member 11/glutathione peroxidase 4 (SLC7A11/GPX4) signaling pathway (Fu et al., 2022).