They found that older age, male gender, previous abdominal surgeries, acute cholecystitis, symptom duration of more than 72 hours, prior history of acute cholecystitis, C-reactive protein value, Conversion from Laparoscopic to Open Cholecystectomy (CLOC) score of more than 6, G10S score of more than 3, diabetes, obesity, emergency LC, and urgent admissions are significant risk factors for conversion of LC to open cholecystectomy [16]. The gene discussed is CRP; the disease is obesity disorder.