In this study, we found that DHM could promote the synthesis and secretion of GLP‐1 in intestinal L cells through the “gut microbiota‐CDCA” pathway; meanwhile, it could regulate the proportion of TCRαβ+ CD8αβ+ IELs and the expression of CD26, reduce the degradation of GLP‐1, thus increasing serum GLP‐1 level and alleviating insulin resistance (Figure 9). This evidence concerns the gene GLP1R and Insulin resistance.