In this study, we found that DHM could promote the synthesis and secretion of GLP‐1 in intestinal L cells through the “gut microbiota‐CDCA” pathway; meanwhile, it could regulate the proportion of TCRαβ+ CD8αβ+ IELs and the expression of CD26, reduce the degradation of GLP‐1, thus increasing serum GLP‐1 level and alleviating insulin resistance (Figure 9). The gene discussed is DPP4; the disease is Insulin resistance.