AKT1 and multiple sclerosis: Common canonical pathways and disease associations among all seven bacteria-associated gene lists, common gene lists, and high-correlation (i.e., > 50%) gene lists included multiple sclerosis, cytokine pathways, Rho signaling, and the PI3K/AKT pathway, suggesting a theme of inflammatory- and immune-related associations between bacterial profiles, host gene expression, and IVP (Figure 2A,B and Figure 3; Supplemental Figure S2A).