In a follow-up study [32] with 22,982 replication samples, 13 loci were associated with renal function and CKD (LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2, and SLC7A9), while seven loci were involved in creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72, and BCAS3). Here, PIP5K1B is linked to chronic kidney disease.