In a follow-up study [32] with 22,982 replication samples, 13 loci were associated with renal function and CKD (LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2, and SLC7A9), while seven loci were involved in creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72, and BCAS3). This evidence concerns the gene CPS1 and chronic kidney disease.