INS and liver cancer: Functional analysis revealed that genes associated with low eGFR were linked to multiple biological processes and pathways, including energy production through ATP synthase activity; protein autoprocessing; regulation of receptor recycling; liver functions, such as liver cancer, thiazolidinedione regulation, LDL pathways, estrogen receptor 1 (ESR1) targets, and insulin signaling; and skeletal muscle function through myosin activity, neuromuscular process, and oligodendrocyte differentiation (Table 3).