Further, Gnetin C alone (40 mg/kg bw, i.p.)and combined with Enz (7 mg/kg bw, i.p.)effectively inhibited AR- and MTA1-promoted tumor progression in castrate-resistant 22Rv1-Luc xenografts, resulting in a lower proliferative index (Ki67) and angiogenesis (CD31), and higher apoptosis (CC3) in tumor tissues. This evidence concerns the gene MKI67 and neoplasm.