DHFR and cancer: ω-3 PUFAs protect normal cells from the ferroptosis attributed to the activation of the interferon regulating factor 3 (IRF3)–solute carrier family seven member 11 (SLC7A11)–lipoxygenase 12 (ALOX12) antioxidant system [14]; however, they promote ferroptosis in certain types of cancer cells associated with the suppression of dihydrofolate reductase (DHFR) and ferroptosis suppressor protein-1 (FSP-1) [15].