In this context, iron overload is capable of triggering the production of pro-inflammatory cytokines, such as TNF-α, IL-1β and INF-γ, which contribute to the formation of ROS and RNS, both of which are capable of causing neurotoxicity and death from neuronal disorders, which are often reported in cases of neurodegenerative diseases [3]. The gene discussed is TNF; the disease is neurodegenerative disease.