A search was conducted in the PubMed database using key words such as “nutrition”, “dyslipidemia”, “atherosclerotic cardiovascular disease”, “lipid biomarkers”, “cardiometabolic risk”, “lifestyle strategies”, “bioactive compounds”, “gut microbiota”, “inflammation”, “insulin sensitivity”, “oxidative stress”, “pharmacological therapies” and “dietary fats” initially identifying approximately 15,000 records. Here, INS is linked to metabolic syndrome.