EDN1 and acute kidney injury: In a prospective study targeting patients with sepsis-induced AKI, RAGE levels demonstrated a positive correlation with E-selectin (r = 0.88), endothelin-1 (ET-1) (r = 0.90), and tumor necrosis factor-α (TNF-α) (r = 0.94) levels, while being inversely correlated with NO levels [102].