The reduced hepatic FA uptake observed here is in agreement with prior literature where the functions of LFABP were examined in vitro in cultured transformed cells, cultured primary hepatocytes from LFABP-/- mice, and in the null mice themselves; a reduction in hepatic FA uptake was also suggested to account for the observed protection against hepatic steatosis in HF-fed whole-body LFABP-/- mice [48,53]. This evidence concerns the gene FABP1 and Hepatic steatosis.