Probiotics such as Lachnospiraceae, B. bifidum, A. muciniphila, L. plantarum, and L. lactis have been extensively studied and have been shown to increase SCFAs, improve the intestinal mucosal barrier, degrade mucin, inhibit the NF-κB pathway, have anti-obesity effects, inhibit the progression of atherosclerosis, and decrease inflammatory mediators [70]. The gene discussed is NFKB1; the disease is Obesity.