IL-17 acts synergistically with TNF-α and IL-1 to induce the release of receptor activator of nuclear factor-kappa B ligand (RANKL), which binds to the receptor RANK on the surface of preosteoclasts, promoting osteoclastogenesis and initiating the process of bone destruction in periodontitis [22,23]. The gene discussed is TNFRSF11A; the disease is periodontitis.