INSR and colorectal carcinoma: The level of nuclear SATB2 immunostaining in tumors of individual CRC patients in relation to the level of SATB2 immunostaining in matched non-involved colorectal tissues is shown in Figure 3A. The average score of SATB2-Ir was lower in CRC cells than in the epithelial cells of non-involved mucosa (3.00 ± 0.16 vs. 3.67 ± 0.10, respectively; p = 0.0008; Figure 3B).