SATB2 expression was found in the vast majority of both primary and metastatic CRCs, suggesting that SATB2 may be used as a diagnostic marker to differentiate CRC from other cancer types [37,39], especially with concomitant immunostaining of cytokeratin 20 [37] or cadherin 17 [40]. This evidence concerns the gene SATB2 and colorectal carcinoma.