MAPK9 and Alzheimer disease: The loss of MAPK9 (betweenness in control 5714.584, betweenness in AD network 738.7555) as a high betweenness gene in the AD network is particularly relevant because it implies a disruption in a key signaling pathway involved in cellular stress responses and transcriptional regulation, probably having extensive implications of network reconfiguration in AD and the potential functional vulnerabilities that may emerge from the disruption of signaling intermediates.