Zhu and colleagues analyzed the DNA methylation levels at a conserved regulatory region (known as the Regulatory T-Cell-Specific Demethylated Region) within the FOXP3 locus in the peripheral blood from a longitudinal cohort consisting of 171 patients with acute CHD, and showed that elevated methylation levels of FOXP3 associated with poor clinical outcomes and severity of atherosclerosis [31]. This evidence concerns the gene FOXP3 and coronary artery disorder.