Here, DNA methylations, annotating to the genes involved in fatty acid and cholesterol metabolism [namely, lipid droplet associated hydrolase (LDAH), apolipoprotein B (APOB), acyl-CoA synthetase members 2A, 5, and 3 (ACSM2A, ACSM5, and ACSM3), carboxylesterase 1 (CES1), carboxylesterase 1 pseudogene 1 (CES1P1), AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), iron-sulfur cluster assembly enzyme (ISCU), SEC14 like lipid binding 2 (SEC14L2), and microsomal triglyceride transfer protein (MTTP)], were hypomethylated in the healthy twin as compared with the twin presenting with premature CAD. The gene discussed is CES1P1; the disease is coronary artery disorder.