Data revealed an association between two CpG sites [mapping to zinc finger homeobox 3 (ZFHX3, cg07786668) and SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a member 4 (SMARCA4, cg17218495)] and myocardial infarction, which was independent of CVD risk factors, such as BMI, blood lipid levels, and type 2 diabetes. This evidence concerns the gene ZFHX3 and myocardial infarction.