In the present study, we aimed to identify the most potent cytotoxic effects of panduratin A and pinostrobin on human NSCLC cell lines, specifically those expressing wild-type EGFR and G12S exon 2 KRAS (A549), as well as the L858R/T790M EGFR (H1975) and wild-type KRAS [36]. Here, EGFR is linked to non-small cell lung carcinoma.