WNK2 and atherosclerosis: Figure 4a shows a comparison of pathway sets between the IR-s and SO-s and IR-f and SO-f pairwise comparisons using Venn diagram. As a result, 120 pathways overlapped between the IR-s and SO-s and IR-f and SO-f groups. We assigned these pathways to the first cluster (Pathway Cluster 1, PC1). The top five overlapping pathways with the most significant Padj value in IR-s vs. SO-s included the glutamatergic synapse, lipid and atherosclerosis, and mitogen-activated protein kinase (MAPK) signaling pathways and others (Figure 4b).