Enrichment analysis showed that the top 10 signaling pathways were alcoholism, systemic lupus erythematosus, viral carcinogenesis, collecting duct acid secretion, Rap1 signaling pathway, ECM–receptor interaction, PI3K-Akt signaling pathway, cell adhesion molecules, cGMP-PKG signaling pathway, and primary bile acid biosynthesis. The gene discussed is AKT1; the disease is systemic lupus erythematosus.