In the process of promoting atherosclerosis, the cGAS-STING pathway has been shown to trigger DNA damage, promote the expression of pro-inflammatory cytokines (such as IL-6) [56], activate macrophages [52], and induce the pyroptosis of vascular endothelial cells [57], as well as other cellular changes, thus promoting atherosclerosis. Here, CGAS is linked to atherosclerosis.