Additionally, chemokines have been shown to play a role in the inflammatory pathogenic of epilepsy [21]; therefore, the top three genes with the highest ES values relative to the significant “C-X-C chemokine receptor type 4 (CXCR4)” pathway were selected: the RAS-like proto-oncogene B (Ralb), Itchy E3 Ubiquitin Protein Ligase (Itch), and FYN Proto-Oncogene of the Src Family Tyrosine Kinase (Fyn). The gene discussed is ITCH; the disease is epilepsy.