They detailed an altered expression of CXCR4 and some of its correlated genes in the brain of patients with different neurodegenerative diseases such as frontotemporal dementia, Parkinson’s disease, or progressive supranuclear palsy, suggesting an important role of microglia and the immune system in neurodegenerative diseases [109]. Here, CXCR4 is linked to Classical progressive supranuclear palsy.