PIEZO2 and amyotrophic lateral sclerosis: In support of this, common- and rare-variant association analyses highlighted a cell-autonomous disease initiation in glutamatergic neurons in ALS [104], and it has been suggested earlier that intrafusal proprioceptive Type Ia fibers are these glutamatergic neurons [11] damaged by the progressive irreversible Piezo2 channelopathy [19,29,95,105].