GDNF and channelopathy: This function of Piezo2 or, more importantly, its deficiency may explain why NGF and GDNF production is heightened in DOMS as a nerve microinjury-derived trophic signaling activation, most likely due to the aforementioned acquired Piezo2 channelopathy-induced impaired Piezo2–Piezo2 and Piezo2–Piezo1 crosstalk.