However, this NGF and GDNF production could be the result of proprioceptive terminal Piezo2 channelopathy-derived switched signaling and impaired cross-frequency coupling of Piezo2–Piezo2 and Piezo2–Piezo1 [29,31], leading to impaired Piezo1-driven cell orientation and adjustment, as was suggested by Sonkodi et al. [42]. This evidence concerns the gene NGF and channelopathy.