The authors of this manuscript suggest that an acquired channelopathy of the principal proprioceptive Piezo2 ion channel in the primary afferents could impair the function of Nav1.1, leading to miswiring or to a switch to the secondary proprioceptive afferents [18,19] and, hence, to connection to inappropriate motoneuron pools. The gene discussed is PIEZO2; the disease is channelopathy.