PIEZO2 and amyotrophic lateral sclerosis: Later, it was also proposed that the acquired channelopathy of Piezo2 in Type Ia terminals could not only disconnect VGLUT1 in motoneurons, but also impair allosteric transmission regulation at a distance through VGLUT2 towards the hippocampal theta rhythm, in a transient fashion in DOMS and in a progressive and irreversible fashion in ALS [29].