One indirect proof of the proprioceptive Piezo2 channelopathy-derived lost ultrafast long-range proton-signaled synchronization towards the hippocampal theta rhythm, or the impairment of ultrafast signaling in the muscle–brain axis, in DOMS was provided by Keriven et al. They demonstrated that paired associative transcranial and peripheral electromagnetic stimulation could mitigate the symptoms of DOMS [28,38]. This evidence concerns the gene PIEZO2 and channelopathy.